European Congress of Virology

28 April - 1 May 2019 in Rotterdam, the Netherlands

European Congress of Virology

28 April - 1 May 2019 in Rotterdam, the Netherlands

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EUROPEAN CONGRESS OF VIROLOGY

28 April – 1 May 2019 in Rotterdam, the Netherlands

Welcome to the European Congress of Virology 2019

Dear colleagues,

With great pleasure, we invite you to participate in the 7th Meeting of The European Society for Virology (ESV), to be held in Rotterdam, the Netherlands, 28 April – 1 May 2019.

ESV was founded in 2008 to provide a forum for investigators of human, animal, plant, fungal, insect, archaeal and bacterial viruses. Our intention is to organize a meeting that will be of interest to this broad range of virologists, in a manner that stimulates discussion and collaboration among scientists active in all aspects of virology. To reflect this, we have installed a scientific advisory board with leading scientists from each of these areas. The meeting will have a mixture of 6 cross disciplinary plenary sessions, and 20 thematic sessions, for which we are currently receiving suggestions from a wide range of virologists. Each session will host a state-of-the art speaker. We are delighted that professor Racaniello has agreed to be present to record some TWIV podcasts. As the meeting will be held in a theatre, we expect to be able to do this in front of an audience, for which we will give preferential access to PhD students and post docs.

We look forward to welcoming you to Rotterdam, a great multi-ethnic urban city and famous for its prominent skyline, the biggest harbor of Europe, fine museums and restaurants, modern architecture and maritime tourist attractions.

Marion Koopmans (Rotterdam) and Ben Berkhout (Amsterdam)

Discover Rotterdam

Rotterdam is the second largest city in the Netherlands and is well known for its port. The port of Rotterdam is the largest port in Europe and third largest in the world. The city is becoming increasingly popular as tourist destination. Rotterdam has been named one of the top cities in the world for travelers according to Lonely Planet’s Best in Travel 2016

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Topics & Program

Sunday
2019-04-28
Grote Zaal
Port of Rotterdam Foyer/Arcadis
Monday
2019-04-29
Grote Zaal
Willem Burger Zaal
Jurriaanse Zaal
Van Weelde Zaal
Port of Rotterdam Foyer/Arcadis
Tuesday
2019-04-30
Grote Zaal
Willem Burger Zaal
Jurriaanse Zaal
Van Weelde Zaal
Port of Rotterdam Foyer/Arcadis
Laurenskerk
Wednesday
2019-05-01
Grote Zaal
Willem Burger Zaal
Jurriaanse Zaal
Van Weelde Zaal
Port of Rotterdam Foyer/Arcadis
Van Beuningen Zaal
Grote Zaal
Port of Rotterdam Foyer/Arcadis
Grote Zaal
Willem Burger Zaal
Jurriaanse Zaal
Van Weelde Zaal
Port of Rotterdam Foyer/Arcadis
Grote Zaal
Willem Burger Zaal
Jurriaanse Zaal
Van Weelde Zaal
Port of Rotterdam Foyer/Arcadis
Laurenskerk
Grote Zaal
Willem Burger Zaal
Jurriaanse Zaal
Van Weelde Zaal
Port of Rotterdam Foyer/Arcadis
Van Beuningen Zaal
16:30 - 20:00
Pre-registration
17:30 - 19:00
Fake Virology and Vaccines: a matter of perspective?

Adolfo García-Sastre: Fake Virology and Vaccines: a scientist perspective

Maarten KeulemansFake Virology and Vaccines: a journalistic perspective

Daan Remarque: Fake Virology and Vaccines: a marketing perspective

Roel Coutinho: Fake Virology and Vaccines: a public health perspective

 

Moderator: Giorgio Palù

19:00 - 20:30
Welcome Reception
09:00 - 10:30
Plenary 1: ONE HEALTH Emerging viruses at the human animal interface

Marion KoopmansGetting ahead of the curve: disease detection 2030

Heinz FeldmannEbola from discovery to prevention

Martin BeerBorna virus, a new zoonotic challenge

 

Chairs: Noël Tordo, Martijn van Hemert

10:30 - 11:00
Break
11:00 - 12:30
Session 1A: Anti-viral Immune-metabolism

Volker Thiel: Mapping the cellular microenvironment where coronaviruses replicate using novel technologies (State of the Art)

 

Selected Orals
Jelke Fros: Newly discovered antiviral pathways control RNA virus replication and drive virus evolution
John Hiscott: Immunometablic regulation of the interferon antiviral response during Dengue virus infection of dendritic cells
Larissa Labzin: Antibody and DNA sensing pathways converge to activate the inflammasome during adenovirus infection of primary human macrophages
Isabel Sola: MERS-CoV 4b protein interferes with the NF-kappaB-dependent innate immune response during infection

 

Chairs: Eric Snijder, Puck van Kasteren

11:00 - 12:30
Session 1B: Emerging viruses at the human animal interface

Selected Orals
Tarja Sironen: Bombali ebolavirus is widespread in Africa: evidence from an infected Mops condylurus bat in south-east Kenya
Cécile Troupin: Serological evidence for the circulation of ebolaviruses in swine in Guinea
Rory de Vries: Endemic paramyxoviruses induce T-cells that cross-recognize zoonotic Nipah virus
S. Stertz: MHC class II proteins mediate corss-species entry of bat influenza viruses
Annika Kratzel: Susceptibility of human and camelid airway epithelium to coronaviruses
Sonia Zuñiga: Role of Middle East respiratory syndrome coronavirus protein 5 on pathogenesis revealed using an engineered mouse-adapted reverse genetics system

 

Chairs: Lia van der Hoek, Berend Jan Bosch

11:00 - 12:30
Session 1C: Viruses and receptors + glycovirology

Raoul de GrootViral attachment to sialoglycan-based receptors: a close association through fleeting interactions (State of the Art)

 

Selected Orals

Franka Debeljak: Characterization of novel determinants of filovirus entry and restriction
Nika Nemanichvili: Fluorescent trimeric hemagglutinins reveal multivalent receptor binding properties
Dagmar Knebel-Mörsdorf: Invasion routes of herpes simplex virus 1 into skin
Robert de Vries: N-glycolylneuraminic acid as a receptor for influenza A viruses

 

Chairs: Hans Nauwynck, Sander Herfst

11:00 - 12:30
Session 1D: Latent and persistent infections

Gabriella Campadelli-Fiume: Environmental virology in the genomics era (State of the Art)

 

Selected Orals

M. Toppinen: Characterization of human DNA viruses persisting in femoral bone
M. Feltkamp: The relevance of BK polyomavirus genotype for BK infection after kidney transplantation
Biswajit Das: A Varicalle Zoster Virus latency model in human embryonic stem cell-derived neurons using conditional translational regulation of viral proteins
N. Atari: Lytic Reactivation of the Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) is Associated with Major Nucleolar Alterations

 

Chairs: Emmanuel Wiertz, Thomas Mertens

12:30 - 14:00
Lunch
12:30 - 14:00
TWIV

Vincent Racaniello

Selected public only

14:00 - 15:30
Session 2A: Antiviral therapy

Andrea Brancale: Computer-aided antiviral drug design (State of the Art)

 

Selected Orals
Daniel Hurdiss: Genome uncoating and its inhibition studies in an acute hemorrhagic conjunctivitis causing variant of Coxsackievirus A24
Emmie de Wit: Nucleotide prodrug remdesivir (GS-5734) protects African green monkeys from lethal Nipah virus Bangladesh challenge
Arianna Loregia: Potent and broad-spectrum compounds that disrupt the subunits interactions of influenza virus polymerase and possess a high barrier to drug-resistance
Miranda de Graaf: Chronic norovirus infections in immunocompromised patients: within-host evolution and therapeutics

 

Chairs: Charles Boucher, Dana Wolf

14:00 - 15:30
Session 2B: Influenza

Ron Fouchier: Determinants of respiratory transmission of influenza A virus (State of the Art)

 

Selected Orals
Susanne Koethe: Modulation of highly pathogenic avian influenza virus H5N8 infection in naturally low pathogenic avian influenza virus-exposed mallard ducks
Erik de Vries: Kinetic analysis of the influenza A virus HA/NA/receptor balance shows NA-dependent rolling on receptor surfaces and enhancement of binding rate by NA
M. Welkers: Polymerase enhancing substitutions that arise during human infection with highly pathogenetic avian influenza A(H5N1) virus
M. Holwerda: Determining the replication kinetics and cellular tropism of the ruminant-associated influenza D virus on human derived airway epithelial cells

 

Chairs: Bruno Lina, Debby van Riel

14:00 - 15:30
Session 2C: Fundamental aspects of the viral life cycle and virus cell-interaction

Mark Harris: A tale of two proteins: hepatitis C virus NS5A and Chikungunya virus nsP3 (State of the Art)

 

Selected Orals
Philip V’kovski: Determination of the molecular microenvironment of viral replication complex with temporal resolution by proximity labelling
Nilda Vanesa Ayala Nunez: Viral invasion of the CNS: how neurotropic viruses hitch a ride on monocytes to cross the blood-brain barrier
Brian Cullen: Viral Epitranscriptomics
V. Kinast: C19orf66 is an interferon-induced inhibitor of HCV replication via restriction of membranous web formation

 

Chairs: Frank van Kuppeveld, Montserrat Barcena

14:00 - 15:30
Session 2D: Viruses and cancer

Sigrun Smola: Immunopathogenesis of HPV-Induced Cancers (State of the Art)

 

Selected Orals

John Hiscott: SIRT1 modulates the sensitivity of prostate cancer cells to VSV oncolysis
P. Erlmann: VSV-GP therapy is effective in HNSCC though direct tumor lysis and stimulation of an anti-tumor immune response
Verena Pfaffinger: Conditionally cytotoxic and controllable rhabdoviruses for oncolytic and immune stimulatory virotherapy
V. Kemp: Arming oncolytic reovirus with GM-CSF gene to enhance immunity

 

Chairs Gabriella Campadelli-Fiume, Mariet Feltkamp

15:30 - 16:00
Break
16:00 - 17:30
Plenary 2: Evolution

Christian Drosten: Emergence and macroevolution of RNA viruses

Santiago Elena: Host variability in resistance genes conditions the evolution of emerging plant RNA viruses

Marco Vignuzzi: Targeting virus evolution and population dynamics

 

Chairs: Ron Fouchier, Bjorn Koel

17:30 - 19:00
ESV assembly

Members only

17:30 - 19:30
Poster walk 1

Drinks & appetizers

09:00 - 10:30
Plenary 3: “THERAPEUTIC” VIROLOGY; Gene therapy and gene editing; Oncolytic Viro-Immunotherapies

Ben BerkhoutTowards an HIV cure using Crispr-Cas technology

John Carr: Modeling and manipulation of aphid-mediated spread of non-persistently transmitted viruses

Rob Hoeben: Exploiting Reovirus Plasticity for Enhancing Antitumor Efficacy in Oncolytic Applications

 

Chairs: Thomas Mertens, Bernadette van den Hoogen

10:30 - 11:00
Break
11:00 - 12:30
Session 3A: Virome/microbiome in health & disease

Christiane Wobus: Transkingdom interactions in the gut: enteric viruses, bacteria, and the host (state of the art)

Rosina Girones: Viral populations of pathogens in irrigation waters, analysis and control (state of the art)

 

Selected Orals

David Nieuwenhuijse: Viral diversity in global urban sewage
Julien Schaeffer: Enteric virus diversity in sewages collected during last decade

 

Chairs: Miranda de Graaf, Wim van der Poel

11:00 - 12:30
Session 3B: Innovative diagnostics, from multiplex serology to metagenetics.

Luiza Barzon: Challenges in the diagnosis of viral infections and the role of new technologies (State of the Art)

 

Selected Orals

Chaturaka Rodrigo: A single nested PCR method for full length dengue virus genome amplification followed by long read next generation sequencing
Sebastian Ulbert: Specific serology in areas of flavivirus co-circulation
Yiannis Manoussopoulos: An image analysis-based machine learning approach for dot-ELISA output evaluation for virus diagnostics
Markus Neumann: Three-dimensional co-cultivation of cells from different species and tissues in a novel bioprinted array as a diagnostic tool for virus

 

Chairs: Bert Niesters, Richard Molenkamp

11:00 - 12:30
Session 3C: Structural virology

Felix Rey: Viral entry from the structural biology perspective (State of the Art)

 

Selected Orals

Martin Delguste: Deciphering the molecular mechanism of herpesvirus attachments to cell surface glycosaminoglycans
T. Bowden: Structural basis for neutralization of Rift Valley fever virus by a protective monoclonal antibody
Matteo Castelli: HCV/E2 hypervariable region 1 sequence-specific conformations shape overall sensitivity to neutralization
Eric Snijder: Common themes in the ultrastructure and function of the coronavirus replication organelle

 

Chairs: Felix Rey, Hanse Langedijk

11:00 - 12:30
Session 3D: Plant virology

Nobuhiro Suzuki: Dicer functions transcriptionally and post-transcriptionally in a multilayer antiviral defense (State of the Art)

 

Selected Orals

Corien Voorburg: Ty-1: insights into an epigenetic antiviral defence mechanism against geminiviruses
Vitantonio Pantaleo: Characterization of plant endogenous va-siRNAs in CaMV and TYLCSV infections reveals silencing of the photosynthetic machinery as unifying feature
M. Mazur: The hunt for 5′-caps: a case study for the cytoplasmic replicating orthospoviruses and orthobunyaciruses
B. Krenz: Analysis of plant virus and stress granules interplay

 

Chairs: Santiago Elena, Richard Kormelink

12:30 - 14:00
Lunch
12:30 - 14:00
TWIV

Vincent Racaniello

Selected public only

12:45 - 13:45
Elsevier author workshop
14:00 - 15:30
Session 4A: Comparative pathogenesis

Thijs Kuiken: Comparative pathogenesis (State of the Art)

 

Selected Orals

Brigitta Laksono: The pathogenesis of measles skin rash
A. Hardy: Species-specific restriction of Bluetongue virus replication correlates to host resilience
Kareem Ezzat: The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Nucleation
Madlin Potratz: Rabies Virus Cell Tropism in 3D – Compasrison of Attenuated, Lab and Field Strains

 

Chairs: Martin Beer, Hélène Verheije

14:00 - 15:30
Session 4B: Vectorborne disease

Selected Orals

Silvia Ricetti: In vitro modeling of patient-specific suscep-tibility to neurotropic flavivirus infection by using induced pluripotent stem cells
V. Avelino-Silva: Predictors of Death in Yellow Fever Virus-Infected Patients
S. Hill
: Emergence of the Zika virus Asian lineage in Angola
Nathalie Jamie Vielle: The human upper respiratory tract epithelium is a target for flaviviruses
Arturo Barbachano-Guerrero: Dengue virus non-structural protein 1 activates endothelial cells
Pei-Shi Yen: Assessing the potential role of Aedes aegypti miRNAs in responding to arbovirus infection

 

Chairs: Jeroen Kortekaas, Chantal Reusken

14:00 - 15:30
Session 4C: Vaccines and broadly neutralising antibodies

Berend Jan Bosch: Protective human monoclonal antibodies targeting different stages of MERS coronavirus entry (State of the Art)

 

Selected Orals

Stefan Metz: Novel DENV and ZIKV subunit vaccine candidates by optimal presentation of quaternary epitopes
Adinda Kok: Avian H5 influenza virses: how to cope with antigenic diversity for vaccine design
Sabrina Schrauf: Phase 2 results: Chikungunya vaccine based on measles vector (MV-CHIK) induces specific immune responses in presence of pre-existing vector immunity
P. Wichgers-Schreur: Four-segmented Rift Valley fever virus provides multispecies protection with a single vaccination

 

Chairs: Guus Rimmelzwaan, Marit van Gils

14:00 - 15:30
Session 4D: Insect viruses

Elisabeth Herniou: AcMNPV adaptive evolution to varying environment (State of the Art)

Vera Ros: Walking with insects: how viruses manipulate insect behaviour (State of the Art)

 

Selected Orals

Benoit Besson: An insect-specific flavivirus produces a unique subgenomic RNA and high amounts of siRNAs
Marcio Hedil Oliveira da Costa: Characterization of a novel dicistrovirus associated with the whitefly Bemisia tabaci

 

Chairs: Monique van Oers, Ronald van Rij

15:30 - 16:00
Break
16:00 - 17:30
Plenary 4: Vector borne

Anna-Bella Failloux: Arboviruses and insect vectors: a never ending dance

Annelies Wilder Smith: Challenges in dengue virus vaccine development?

Jolanda Smit: Dissecting virus:host interactions during the replication cycle of dengue virus and chikungunya virus

 

Chairs: Anna Pappa, Marion Koopmans

17:30 - 19:00
Poster walk 2

Drinks and appetizers

20:00 - 00:00
Congress Diner
  • Time: 20.00-24.00 hrs
  • Location: Laurenskerk, Grotekerkplein 27, 3011 GC Rotterdam
  • (approximately 15 minutes by foot from the congress venue)
  • Price: € 50,- includes drinks, dinner and DJ
08:30 - 10:00
Plenary 5: Vaccines

Bart Haagmans: Vaccines against emerging viruses

Marie-Paule Kieny: Vaccine development in a public health emergency

Rogier Sanders: Inducing HIV-1 neutralizing antibodies by stabilized native-like envelope trimers

 

Chairs: Thomas Mettenleiter, Xander de Haan

10:00 - 10:30
Break
10:30 - 12:00
Session 5A: Evolution

Selected Orals

Ganna Galitska: A strategy of human Cytomegalovirus to escape interferon beta-induced APOBEC3G editing activity

Pablo Matinez Vincente: A cytomegalovirus-encoded soluble CD48 decoy receptor impairs 2B4-mediated NK cell responses
Ab Osterhaus: Identification of a Noval Pestivirus in a Cetacean Species
Nuna Faria: Genomic and epidemiological surveillance of arboviruses in Brazil
D. Pascall: Whole genome phylogenetics informs about the mechanisms of bluetongue virus serotype 8 emergence and spread in Europe
Darlan Da Silva Candido: Evolution and spread of the ECSA chikungunya virus in the Americas

 

Chairs: Colin Russell, Nancy Beerens

10:30 - 12:00
Session 5B: Congenital and neonatal infections

Dana Wolf: Human cytomegalovirus transmission and local immunity in the maternal-fetal interface (State of the Art)

 

Selected Orals
Julia
Eder: Human vaginal and skin dendritic cell subsets control Zika virus infection
Francesco Bonfante: Is adaptation to the placenta a strain-dependent feature of ZIKA viruses?
Noreen Mumtaz: Zika virus infection perturbs osteoblast function
Teemu Smura: The evolution of Zika virus during mother to foetus transmission

 

Chairs: Bert Niesters and Pieter Fraaij

10:30 - 12:00
Session 5C: Focus on BSL4 pathogens

Stephan Günther: Lassa Fever—West African Experience (State of the Art)

 

Selected Orals

Natascha Rickett: Determinants of patient survival following acute Ebola virus infection: A transcriptomic approach
V. Munster: Preclinical development of ChAdOx1-vectored vaccines against CEPI and WHO blueprint highly pathogenic viruses: MERS-CoV, Nipah virus and Lassa virus
Francisco Jose Zapatero-Belinchon: The promiscuous virus: filoviruses use redundant cell surface proteins for productive entry regardless of the cellular background
Alexander Freiberg: Nipah virus infection of neuron/astrocyte co-cultures is inhibited by addition of interferon beta with early decreases in astrocytic infection

 

Chairs: Vincent Munster, Barry Rockx

10:30 - 12:00
Session 5D: Focus on veterinary diseases

Alain Vanderplasschen: The carp and the herpesvirus: not a fable but a fascinating story of host-virus interactions (State of the Art)

 

Selected Orals

Jan Hendrik Forth: Ancient endogenous African swine fever virus-like elements in a soft tick genome – a virus-vector “arms race”?
S. Descamps: Beyond gut instinct: Metabolic short-chain fatty acids moderate the pathogenesis of equine herpesvirus-1
Eva Mazzetto: Replication and attachment of influenza D virsuses of bovine and swine orirgin in sheep respiratory explants
Nancy Beerens: Genetic relationship between poultry and wild bird viruses during the higly pahtogenic avian influenza H5N6 epidemic in the Netherlands

 

Chairs: Massimo Palmarini, Paul Wichgers Schreur

12:00 - 13:30
Lunch
12:10 - 13:25
How can we help you?

12:10-12:20 The European Virus Archive goes Global: Christine Prat
12:25-12:40 Erinha: Audrey Richard
12:40-12:55 Euro-BioImaging: Research Infrastructures by Frauke Leitner
12:55-13:10 Instruct-ERIC: Naomi Gray
13:10-13:25 Infravec2: Ken Vermick

 

Chair: Frank van Kuppeveld

12:15 - 13:15
Archives in Virology lunch session hosted by Editor in Chief Tim Skern

Free entry

13:30 - 15:15
Plenary 6: HIV, HBV, HCV: problems solved?

Roel Coetinho: The challenge of Hepatitis C elimination

Ralf Bartenschlager: Hepatitis C Virus Elimination; Achievements and Challenges

 

Selected Orals
Alfredo Garzino-Demo: Block and Kill: a new approach to a functional cure for HIV, preventing HIV reactivation and inducing selective apoptosis of HIV-infected cells
Renee van der Sluis: Efficient HIV latency reversal with immune checkpoint blockade in a primary T-cell latency model
Stephan Urban: Results of a phase 2 Clinical Trial to assess safety and efficacy of Myrcludex B in combination with PeIFNa in HBV/HDV co-infected patients

 

Chairs: Giorgio Palù, Alexander Pasternak

15:15 - 15:45
Closing & Award Ceremony
Select date to see events.

European Congress of Virology
ECV 2019
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For questions regarding sponsoring the ECV 2019 congress, please contact:  ecv2019@erasmusmc.nl .

Venue

WE INVITE YOU AT DE DOELEN CONGRESS CENTER IN ROTTERDAM

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