I graduated from Plymouth Polytechnic in 1983 with a degree in Biological Sciences, before PhD study with Ron Hay at the Institute of Virology in Glasgow on adenovirus DNA replication. After a post-doctoral position studying baculoviruses with Bob Possee at the NERC Institute of Virology in Oxford I moved back to Glasgow to the Department of Veterinary Pathology to study the HIV-1 Nef protein with Jim Neil. I was awarded an MRC AIDS Directed Programme Senior Fellowship in 1994, and subsequently took up a Lectureship at the University of Leeds in 1997 where I started to develop research interests in hepatitis C virus, funded by the MRC, BBSRC and Wellcome Trust. In 2011 I was awarded a Wellcome Trust Senior Investigator Award. I am Editor-in-Chief of the Journal of General Virology, published by the Microbiology Society, and have previously been a member of the Council of the Society and the Chair of the Scientific Conferences Committee.